But again keep in mind this was a single study, the question is: Does long-term aerobic and resistance exercise blunt muscle hypertrophy? Well, in this month’s Journal of Applied Physiology, an interesting article titled “Aerobic exercise does not compromise muscle hypertrophy response to short-term resistance training” should put your mind at ease. The study was done for five weeks and tested the effects on combined weight lifting with cardio (45 minutes). It was interesting in the way that they performed the study, they used one leg for resistance exercise only while the other leg they used for resistance exercise and one-legged cycling. At the end of the study, there was no difference in the muscle sizes between both the legs measured. In fact, they found slightly greater increases in muscle mass with the combination of cardio and resistance exercise. The results suggest that aerobic exercise when combined with resistance exercise does not suppress muscle gains and may even be beneficial.